The family is revealed to live in London, Ontario, Canada, when George is reading a newspaper titled London Chronicle in episode "Don't Take a Tip From Me." Also, in another episode, "All Systems No Go," he refers to himself as "George from London," and in "Dinner Guest," when Lizzie explains how her dad's been to London and Paris, George remarks, "I've been to London and Paris...Ontario." Season 1 episodes of Life with Derek were filmed in Corner Brook, Newfoundland and Labrador, Canada.
Prior to becoming members of a blended family, Casey and Derek were firmly comfortable in their roles as first-born children, including having a major influence on how family decisions were made.
When their families blend, each strives for dominance: Casey by "sticking to the rules" and Derek by asserting himself with both force and manipulation.
Meanwhile, it's obvious to Nora (Joy Tanner) and Casey that Derek is doing his best to sabotage any chance with Sally.
And since Derek is much nicer when she's around, they decide to matchmake by inviting Sally over to the house.
Derek/Casey could be considered the fandom's OTP, as nearly all the fans like the pairing even when the network & creator's best efforts in the contrary.